SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine

SLC26A6 (also known as putative anion transporter 1 [PAT1]) is a Cl(–)/HCO(3)(–) exchanger expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl(–) and fluid absorption. Here, high-throughput screening of 50,000 synthetic small molecules in cells expressing PAT1 and a h...

Descripción completa

Detalles Bibliográficos
Autores principales: Cil, Onur, Haggie, Peter M., Tan, Joseph-Anthony Tapia, Rivera, Amber A., Verkman, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262356/
https://www.ncbi.nlm.nih.gov/pubmed/34100381
http://dx.doi.org/10.1172/jci.insight.147699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262356/
https://www.ncbi.nlm.nih.gov/pubmed/34100381
http://dx.doi.org/10.1172/jci.insight.147699

Ejemplares similares