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Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program

Tissue-resident memory T cells (T(RM)) provide frontline defense against infectious diseases and contribute to antitumor immunity; however, aside from the necessity of TGF-β, knowledge regarding T(RM)-inductive cues remains incomplete, particularly for human cells. Oxygen tension is an environmental...

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Detalles Bibliográficos
Autores principales: Hasan, Farah, Chiu, Yulun, Shaw, Rebecca M., Wang, Junmei, Yee, Cassian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262358/
https://www.ncbi.nlm.nih.gov/pubmed/34027895
http://dx.doi.org/10.1172/jci.insight.138970