Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake

Patients with chronic kidney disease (CKD) and end-stage renal disease suffer from increased cardiovascular events and cardiac mortality. Prior studies have demonstrated that a portion of this enhanced risk can be attributed to the accumulation of microbiota-derived toxic metabolites, with most stud...

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Detalles Bibliográficos
Autores principales: Chaves, Lee D., Abyad, Sham, Honan, Amanda M., Bryniarski, Mark A., McSkimming, Daniel I., Stahura, Corrine M., Wells, Steven C., Ruszaj, Donna M., Morris, Marilyn E., Quigg, Richard J., Yacoub, Rabi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262368/
https://www.ncbi.nlm.nih.gov/pubmed/33914709
http://dx.doi.org/10.1172/jci.insight.144410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262368/
https://www.ncbi.nlm.nih.gov/pubmed/33914709
http://dx.doi.org/10.1172/jci.insight.144410

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