Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm

DNA mismatch repair (MMR) proteins play an important role in maintaining genome stability, both in somatic and in germline cells. Loss of MLH1, a central MMR protein, leads to infertility and to microsatellite instability (MSI) in spermatocytes, however, the effect of Mlh1 heterozygosity on germline...

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Detalles Bibliográficos
Autores principales: Shrestha, Kul S, Tuominen, Minna M, Kauppi, Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Manuscripts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262379/
https://www.ncbi.nlm.nih.gov/pubmed/33740045
http://dx.doi.org/10.1093/mutage/geab010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262379/
https://www.ncbi.nlm.nih.gov/pubmed/33740045
http://dx.doi.org/10.1093/mutage/geab010

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