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Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm
DNA mismatch repair (MMR) proteins play an important role in maintaining genome stability, both in somatic and in germline cells. Loss of MLH1, a central MMR protein, leads to infertility and to microsatellite instability (MSI) in spermatocytes, however, the effect of Mlh1 heterozygosity on germline...
Autores principales: | Shrestha, Kul S, Tuominen, Minna M, Kauppi, Liisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262379/ https://www.ncbi.nlm.nih.gov/pubmed/33740045 http://dx.doi.org/10.1093/mutage/geab010 |
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