α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH). However, mechanisms and therapeutic strategies to mitigate RV fibrosis remain unrealized. Previously, we identified that cardiac fibrobl...

Descripción completa

Detalles Bibliográficos
Autores principales: Vang, Alexander, da Silva Gonçalves Bos, Denielli, Fernandez-Nicolas, Ana, Zhang, Peng, Morrison, Alan R., Mancini, Thomas J., Clements, Richard T., Polina, Iuliia, Cypress, Michael W., Jhun, Bong Sook, Hawrot, Edward, Mende, Ulrike, O-Uchi, Jin, Choudhary, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262476/
https://www.ncbi.nlm.nih.gov/pubmed/33974567
http://dx.doi.org/10.1172/jci.insight.142945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262476/
https://www.ncbi.nlm.nih.gov/pubmed/33974567
http://dx.doi.org/10.1172/jci.insight.142945

Ejemplares similares