Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency

The development of antibody-drug conjugates (ADCs) has significantly been advanced in the past decade given the improvement of payloads, linkers and conjugation methods. In particular, linker design plays a critical role in modulating ADC stability in the systemic circulation and payload release eff...

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Detalles Bibliográficos
Autores principales: Su, Dian, Zhang, Donglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262647/
https://www.ncbi.nlm.nih.gov/pubmed/34248637
http://dx.doi.org/10.3389/fphar.2021.687926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262647/
https://www.ncbi.nlm.nih.gov/pubmed/34248637
http://dx.doi.org/10.3389/fphar.2021.687926

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