In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

Herpesvirus entry and spread requires fusion of viral and host cell membranes, which is mediated by the conserved surface glycoprotein B (gB). Upon activation, gB undergoes a major conformational change and transits from a metastable prefusion to a stable postfusion conformation. Although gB is a st...

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Detalles Bibliográficos
Autores principales: Vallbracht, Melina, Lötzsch, Henriette, Klupp, Barbara G., Fuchs, Walter, Vollmer, Benjamin, Grünewald, Kay, Backovic, Marija, Rey, Felix A., Mettenleiter, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262866/
https://www.ncbi.nlm.nih.gov/pubmed/33947756
http://dx.doi.org/10.1128/mBio.00557-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262866/
https://www.ncbi.nlm.nih.gov/pubmed/33947756
http://dx.doi.org/10.1128/mBio.00557-21

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