Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate

Pseudomonas aeruginosa causes life-threatening infections that are associated with antibiotic failure. Previously, we identified the antibiotic G2637, an analog of arylomycin, targeting bacterial type I signal peptidase, which has moderate potency against P. aeruginosa. We hypothesized that an antib...

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Detalles Bibliográficos
Autores principales: Kajihara, Kimberly K., Pantua, Homer, Hernandez-Barry, Hilda, Hazen, Meredith, Deshmukh, Kiran, Chiang, Nancy, Ohri, Rachana, Castellanos, Erick R., Martin, Lynn, Matsumoto, Marissa L., Payandeh, Jian, Storek, Kelly M., Schneider, Kellen, Smith, Peter A., Koehler, Michael F. T., Tsai, Siao Ping, Vandlen, Richard, Loyet, Kelly M., Nakamura, Gerald, Pillow, Thomas, Seshasayee, Dhaya, Kapadia, Sharookh B., Hazenbos, Wouter L. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262897/
https://www.ncbi.nlm.nih.gov/pubmed/34061593
http://dx.doi.org/10.1128/mBio.00202-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262897/
https://www.ncbi.nlm.nih.gov/pubmed/34061593
http://dx.doi.org/10.1128/mBio.00202-21

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