Cargando…

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

The HIV-1 latent reservoir is the major barrier to an HIV cure. Due to low levels or lack of transcriptional activity, HIV-1 latent proviruses in vivo are not easily detectable and cannot be targeted by either natural immune mechanisms or molecular therapies based on protein expression. To target th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Yue, Schubert, Heidi L., Singh, Parmit K., Martins, Laura J., Engelman, Alan N., D’Orso, Iván, Hill, Christopher P., Planelles, Vicente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262898/ https://www.ncbi.nlm.nih.gov/pubmed/34154414 http://dx.doi.org/10.1128/mBio.01098-21

Ejemplares similares

Mathematical Models of HIV-1 Dynamics, Transcription, and Latency
por: D’Orso, Iván, et al.
Publicado: (2023)

HIV-1 Proviral Transcription and Latency in the New Era
por: Shukla, Ashutosh, et al.
Publicado: (2020)

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6
por: Jang, Sooin, et al.
Publicado: (2019)

Requirement for cleavage factor II(m) in the control of alternative polyadenylation in breast cancer cells
por: Turner, Rachael E., et al.
Publicado: (2020)

Transcriptional activity regulates alternative cleavage and polyadenylation
por: Ji, Zhe, et al.
Publicado: (2011)

HIV‐1‐induced type I IFNs promote viral latency in macrophages
por: Dickey, Laura L., et al.
Publicado: (2022)

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function
por: Garrido, Carolina, et al.
Publicado: (2016)

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo
por: Spivak, Adam M., et al.
Publicado: (2016)

Cleavage and polyadenylation: Ending the message expands gene regulation
por: Neve, Jonathan, et al.
Publicado: (2017)

Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex
por: Hill, Chris H., et al.
Publicado: (2019)

A compendium of conserved cleavage and polyadenylation events in mammalian genes
por: Wang, Ruijia, et al.
Publicado: (2018)

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma
por: Chen, Shi-lu, et al.
Publicado: (2021)

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
por: Kauder, Steven E., et al.
Publicado: (2009)

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents
por: Sorensen, Eric S., et al.
Publicado: (2020)

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
por: Trypsteen, Wim, et al.
Publicado: (2019)

Analysis of alterative cleavage and polyadenylation by 3′ region extraction and deep sequencing
por: Hoque, Mainul, et al.
Publicado: (2012)

Direct Sequencing of Arabidopsis thaliana RNA Reveals Patterns of Cleavage and Polyadenylation
por: Sherstnev, Alexander, et al.
Publicado: (2012)

hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
por: Fischl, Harry, et al.
Publicado: (2019)

Efficient Translation of Dnmt1 Requires Cytoplasmic Polyadenylation and Musashi Binding Elements
por: Rutledge, Charlotte E., et al.
Publicado: (2014)

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster
por: Liu, Xiaochuan, et al.
Publicado: (2017)

Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control
por: Li, Wencheng, et al.
Publicado: (2016)

PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
por: Yang, Yan, et al.
Publicado: (2016)

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential
por: Malka, Yuval, et al.
Publicado: (2022)

Spatial and Genomic Correlates of HIV-1 Integration Site Targeting
por: Singh, Parmit Kumar, et al.
Publicado: (2022)

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
por: D’Orso, Iván, et al.
Publicado: (2010)

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
por: D’Orso, Iván, et al.
Publicado: (2010)

HIV-1 Latency and Latency Reversal: Does Subtype Matter?
por: Sarabia, Indra, et al.
Publicado: (2019)

Correction: PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
por: Yang, Yan, et al.
Publicado: (2016)

Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation
por: Neve, Jonathan, et al.
Publicado: (2016)

Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation
por: Fontes, Mariana M., et al.
Publicado: (2017)

Exploring the Impact of Cleavage and Polyadenylation Factors on Pre-mRNA Splicing Across Eukaryotes
por: Lepennetier, Gildas, et al.
Publicado: (2017)

Electrostatic Interactions between CSTF2 and pre-mRNA Drive Cleavage and Polyadenylation
por: Masoumzadeh, Elahe, et al.
Publicado: (2022)

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation
por: Lee, Si Young, et al.
Publicado: (2020)

Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the Long Terminal Repeat
por: Viglianti, Gregory A., et al.
Publicado: (2021)

Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunits
por: Rao, Suryadevara, et al.
Publicado: (2009)

A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation
por: Gruber, Andreas J., et al.
Publicado: (2016)

ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
por: Ramirez, Nora-Guadalupe P., et al.
Publicado: (2022)

New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention
por: Lewis, Catherine A., et al.
Publicado: (2023)

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
por: Kaida, Daisuke, et al.
Publicado: (2010)

Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
por: Zhou, Zhipeng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vfdnvm8lebjbrifa94adcsog88