Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides

The catalytic subunit of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) Nsp12 has a unique nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain that transfers nucleoside monophosphates to the Nsp9 protein and the nascent RNA. The NiRAN...

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Detalles Bibliográficos
Autores principales: Wang, Bing, Svetlov, Vladimir, Wolf, Yuri I., Koonin, Eugene V., Nudler, Evgeny, Artsimovitch, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262916/
https://www.ncbi.nlm.nih.gov/pubmed/34154407
http://dx.doi.org/10.1128/mBio.01423-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262916/
https://www.ncbi.nlm.nih.gov/pubmed/34154407
http://dx.doi.org/10.1128/mBio.01423-21

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