Genotype imputation in case-only studies of gene-environment interaction: validity and power

Case-only (CO) studies are a powerful means to uncover gene-environment (G × E) interactions for complex human diseases. Moreover, such studies may in principle also draw upon genotype imputation to increase statistical power even further. However, genotype imputation usually employs healthy control...

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Detalles Bibliográficos
Autores principales: Aleknonytė-Resch, Milda, Szymczak, Silke, Freitag-Wolf, Sandra, Dempfle, Astrid, Krawczak, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263402/
https://www.ncbi.nlm.nih.gov/pubmed/34041609
http://dx.doi.org/10.1007/s00439-021-02294-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263402/
https://www.ncbi.nlm.nih.gov/pubmed/34041609
http://dx.doi.org/10.1007/s00439-021-02294-z

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