Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

Metformin increased cellular ROS levels in AsPC-1 pancreatic cancer cells, with minimal effect in HDF, human primary dermal fibroblasts. Metformin reduced cellular ATP levels in HDF, but not in AsPC-1 cells. Metformin increased AMPK, p-AMPK (Thr172), FOXO3a, p-FOXO3a (Ser413), and MnSOD levels in HD...

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Detalles Bibliográficos
Autores principales: Warkad, Madhuri Shende, Kim, Chea-Ha, Kang, Beom-Goo, Park, Soo-Hyun, Jung, Jun-Sub, Feng, Jing-Hui, Inci, Gozde, Kim, Sung-Chan, Suh, Hong-Won, Lim, Soon Sung, Lee, Jae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263563/
https://www.ncbi.nlm.nih.gov/pubmed/34234193
http://dx.doi.org/10.1038/s41598-021-93270-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263563/
https://www.ncbi.nlm.nih.gov/pubmed/34234193
http://dx.doi.org/10.1038/s41598-021-93270-0

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