Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

Here we report the pharmacologic blockade of voltage-gated sodium ion channels (Na(V)s) by a synthetic saxitoxin derivative affixed to a photocleavable protecting group. We demonstrate that a functionalized saxitoxin (STX-eac) enables exquisite spatiotemporal control of Na(V)s to interrupt action po...

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Detalles Bibliográficos
Autores principales: Elleman, Anna V., Devienne, Gabrielle, Makinson, Christopher D., Haynes, Allison L., Huguenard, John R., Du Bois, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263607/
https://www.ncbi.nlm.nih.gov/pubmed/34234116
http://dx.doi.org/10.1038/s41467-021-24392-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263607/
https://www.ncbi.nlm.nih.gov/pubmed/34234116
http://dx.doi.org/10.1038/s41467-021-24392-2

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