GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways. Previous genetic studies have focussed on identifying common variants associated with LOY, which we now extend to rarer, protein-coding...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yajie, Stankovic, Stasa, Koprulu, Mine, Wheeler, Eleanor, Day, Felix R., Lango Allen, Hana, Kerrison, Nicola D., Pietzner, Maik, Loh, Po-Ru, Wareham, Nicholas J., Langenberg, Claudia, Ong, Ken K., Perry, John R. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263756/
https://www.ncbi.nlm.nih.gov/pubmed/34234147
http://dx.doi.org/10.1038/s41467-021-24504-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263756/
https://www.ncbi.nlm.nih.gov/pubmed/34234147
http://dx.doi.org/10.1038/s41467-021-24504-y

Ejemplares similares