Cargando…

Calmodulin-dependent KCNE4 dimerization controls membrane targeting

The voltage-dependent potassium channel Kv1.3 participates in the immune response. Kv1.3 is essential in different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of Kv1.3 is linked to autoimmune diseases, fine-tuning its function is crucial for leuko...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roig, Sara R., Solé, Laura, Cassinelli, Silvia, Colomer-Molera, Magalí, Sastre, Daniel, Serrano-Novillo, Clara, Serrano-Albarrás, Antonio, Lillo, M. Pilar, Tamkun, Michael M., Felipe, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263776/ https://www.ncbi.nlm.nih.gov/pubmed/34234241 http://dx.doi.org/10.1038/s41598-021-93562-5

Ejemplares similares

Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex
por: Solé, Laura, et al.
Publicado: (2020)

KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology
por: Vallejo-Gracia, Albert, et al.
Publicado: (2021)

Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
por: Serrano-Novillo, Clara, et al.
Publicado: (2019)

The unconventional biogenesis of Kv7.1-KCNE1 complexes
por: Oliveras, Anna, et al.
Publicado: (2020)

The Potassium Channel Odyssey: Mechanisms of Traffic and Membrane Arrangement
por: Capera, Jesusa, et al.
Publicado: (2019)

Differential Association between HERG and KCNE1 or KCNE2
por: Um, Sung Yon, et al.
Publicado: (2007)

Endocytosis: A Turnover Mechanism Controlling Ion Channel Function
por: Estadella, Irene, et al.
Publicado: (2020)

The KCNE Tango – How KCNE1 Interacts with Kv7.1
por: Wrobel, Eva, et al.
Publicado: (2012)

Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2
por: Li, Pan, et al.
Publicado: (2014)

Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2
por: Wang, Yuhong, et al.
Publicado: (2012)

Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4
por: Abbott, Geoffrey W.
Publicado: (2016)

Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors
por: Serrano-Novillo, Clara, et al.
Publicado: (2020)

Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression
por: Braun, Chen, et al.
Publicado: (2021)

KCNE1 and KCNE3 β-Subunits Regulate Membrane Surface Expression of Kv12.2 K(+) Channels In Vitro and Form a Tripartite Complex In Vivo
por: Clancy, Sinead M., et al.
Publicado: (2009)

KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel
por: Nakajo, Koichi, et al.
Publicado: (2007)

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
por: Barro-Soria, Rene, et al.
Publicado: (2014)

Investigating Structural Dynamics of KCNE3 in Different Membrane Environments Using Molecular Dynamics Simulations
por: Asare, Isaac K., et al.
Publicado: (2022)

Secondary Structure of a KCNE Cytoplasmic Domain
por: Rocheleau, Jessica M., et al.
Publicado: (2006)

S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2.1 subunit
por: Roig, Sara R., et al.
Publicado: (2022)

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting
por: Wrobel, Eva, et al.
Publicado: (2016)

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1
por: Erlandsdotter, Lisa-Marie, et al.
Publicado: (2023)

Structural Investigation of the Transmembrane Domain of KCNE1 in Proteoliposomes
por: Sahu, Indra D., et al.
Publicado: (2014)

KCNE2 and gastric cancer: bench to bedside
por: Abbott, Geoffrey W., et al.
Publicado: (2016)

Expression and Localization of Kcne2 in the Vertebrate Retina
por: Lindner, Moritz, et al.
Publicado: (2020)

Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits
por: Roig, Sara R., et al.
Publicado: (2022)

Trafficking mechanisms underlying Na(v) channel subcellular localization in neurons
por: Solé, Laura, et al.
Publicado: (2019)

Novel Time-Lapse Parameters Correlate with Embryo Ploidy and Suggest an Improvement in Non-Invasive Embryo Selection
por: Serrano-Novillo, Clara, et al.
Publicado: (2023)

Arrhythmogenic KCNE gene variants: current knowledge and future challenges
por: Crump, Shawn M., et al.
Publicado: (2014)

A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity
por: Hu, Bin, et al.
Publicado: (2019)

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
por: Kasuya, Go, et al.
Publicado: (2022)

Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K(+) conductance in the proximal tubule
por: Neal, A M, et al.
Publicado: (2011)

Structural basis for KCNE3 modulation of potassium recycling in epithelia
por: Kroncke, Brett M., et al.
Publicado: (2016)

The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study
por: Hedley, Paula L, et al.
Publicado: (2011)

KCNE Regulation of K(+) Channel Trafficking – a Sisyphean Task?
por: Kanda, Vikram A., et al.
Publicado: (2012)

An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus
por: Sand, Philipp G., et al.
Publicado: (2010)

Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization
por: Vinogradova, Maia V., et al.
Publicado: (2013)

PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
por: Momin, Afaque A., et al.
Publicado: (2022)

N-Terminal Arginines Modulate Plasma-Membrane Localization of Kv7.1/KCNE1 Channel Complexes
por: Girmatsion, Zenawit, et al.
Publicado: (2011)

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer
por: Comes, Núria, et al.
Publicado: (2013)

Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes
por: Lussier, Yoann, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_40u3okbcb01ib66cspv9au7dov