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A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain
Voltage-gated sodium, potassium, and calcium channels consist of four voltage-sensing domains (VSDs) that surround a central pore domain and transition from a down state to an up state in response to membrane depolarization. While many types of drugs bind pore domains, the number of organic molecule...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263925/ https://www.ncbi.nlm.nih.gov/pubmed/34228045 http://dx.doi.org/10.1085/jgp.202012833 |