Cargando…

A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain

Voltage-gated sodium, potassium, and calcium channels consist of four voltage-sensing domains (VSDs) that surround a central pore domain and transition from a down state to an up state in response to membrane depolarization. While many types of drugs bind pore domains, the number of organic molecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Chang, Hong, Liang, Riahi, Saleh, Lim, Victoria T., Tobias, Douglas J., Tombola, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263925/ https://www.ncbi.nlm.nih.gov/pubmed/34228045 http://dx.doi.org/10.1085/jgp.202012833

Ejemplares similares

HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions
por: Zhao, Chang, et al.
Publicado: (2021)

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity
por: Tombola, Francesco, et al.
Publicado: (2009)

Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations
por: Lim, Victoria T., et al.
Publicado: (2020)

Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling
por: Hong, Liang, et al.
Publicado: (2015)

Evidence for Functional Diversity between the Voltage-Gated Proton Channel Hv1 and Its Closest Related Protein HVRP1
por: Kim, Iris H., et al.
Publicado: (2014)

The Hv1 proton channel responds to mechanical stimuli
por: Pathak, Medha M., et al.
Publicado: (2016)

Structure and hydration of membranes embedded with voltage-sensing domains
por: Krepkiy, Dmitriy, et al.
Publicado: (2009)

Cholesterol inhibits human voltage-gated proton channel hHv1
por: Han, Shuo, et al.
Publicado: (2022)

The Cooperative Voltage Sensor Motion that Gates a Potassium Channel
por: Pathak, Medha, et al.
Publicado: (2005)

CMS ECAL High Voltage (HV) - Test Cards
por: Cussans, D
Publicado: (2006)

Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation
por: Zhao, Chang, et al.
Publicado: (2021)

Domain-to-domain coupling in voltage-sensing phosphatase
por: Sakata, Souhei, et al.
Publicado: (2017)

Stabilization of Accelerating Voltage in HV Accelerator-tandem for Neutron Capture Therapy
por: Veis, M E, et al.
Publicado: (2002)

Zn(2+) to probe voltage-gated proton (Hv1) channels
por: Larsson, H. Peter
Publicado: (2020)

Role of voltage-gated proton channel (Hv1) in cancer biology
por: Alvear-Arias, Juan J., et al.
Publicado: (2023)

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP
por: Villalba-Galea, Carlos A., et al.
Publicado: (2009)

Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain
por: Mishina, Yukiko, et al.
Publicado: (2014)

Mechanically-primed voltage-gated proton channels from angiosperm plants
por: Zhao, Chang, et al.
Publicado: (2023)

A specialized molecular motion opens the Hv1 voltage-gated proton channel
por: Mony, Laetitia, et al.
Publicado: (2015)

Voltage-sensing phosphatase modulation by a C2 domain
por: Castle, Paul M., et al.
Publicado: (2015)

Prototype of High Voltage distributor for station 3,4,5 HV anode
por: Cicalo, C.
Publicado: (2004)

CMS ECAL Endcap (EE) - High Voltage (HV) card test box
por: Droege, M
Publicado: (2007)

Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels
por: Okochi, Yoshifumi, et al.
Publicado: (2021)

Microglial voltage-gated proton channel Hv1 in spinal cord injury
por: Zheng, Jiaying, et al.
Publicado: (2021)

Voltage and pH difference across the membrane control the S4 voltage-sensor motion of the Hv1 proton channel
por: Schladt, T. Moritz, et al.
Publicado: (2020)

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel
por: Zhao, Juan, et al.
Publicado: (2016)

Design and characterisation of High-Voltage CMOS (HV-CMOS) detectors for particle physics experiments
por: Franks, Matthew Lewis
Publicado: (2022)

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels
por: Lamothe, Shawn M, et al.
Publicado: (2020)

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel
por: Arrigoni, Cristina, et al.
Publicado: (2013)

Calcium-driven regulation of voltage-sensing domains in BK channels
por: Lorenzo-Ceballos, Yenisleidy, et al.
Publicado: (2019)

The Voltage–gated Proton Channel, Hv1, Enhances Brain Damage from Ischemic Stroke
por: Wu, Long–Jun, et al.
Publicado: (2012)

Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice
por: Pang, Huimin, et al.
Publicado: (2020)

Functions and Mechanisms of the Voltage-Gated Proton Channel Hv1 in Brain and Spinal Cord Injury
por: He, Junyun, et al.
Publicado: (2021)

Caution Is Required in Interpretation of Mutations in the Voltage Sensing Domain of Voltage Gated Channels as Evidence for Gating Mechanisms
por: Kariev, Alisher M., et al.
Publicado: (2015)

Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain
por: Manville, Rían W., et al.
Publicado: (2023)

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
por: Lörinczi, Éva, et al.
Publicado: (2015)

Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains
por: Hsu, Eric J., et al.
Publicado: (2017)

Distinct roles for Ca(V)1.1’s voltage-sensing domains
por: Short, Ben
Publicado: (2021)

Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1)
por: Kawai, Takafumi, et al.
Publicado: (2017)

The Voltage-Gated Hv1 H(+) Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells
por: Cozzolino, Marco, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ijod732dro51cethmgag6cj42r