A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells

Lapachol is a well-studied natural product that has been receiving great interest due to its anticancer properties that target oxidative stress. In the present work, two novel lapachol-containing ruthenium(II) complexes [Ru(Lap)(dppm)(bipy)]PF(6) (1) and [Ru(Lap)(dppm)(phen)]PF(6) (2) [Lap = lapacho...

Descripción completa

Detalles Bibliográficos
Autores principales: De Grandis, Rone A., Oliveira, Katia M., Guedes, Adriana P. M., dos Santos, Patrick W. S., Aissa, Alexandre F., Batista, Alzir A., Pavan, Fernando R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264259/
https://www.ncbi.nlm.nih.gov/pubmed/34249731
http://dx.doi.org/10.3389/fonc.2021.682968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264259/
https://www.ncbi.nlm.nih.gov/pubmed/34249731
http://dx.doi.org/10.3389/fonc.2021.682968

Ejemplares similares