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Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids...

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Detalles Bibliográficos
Autores principales: Zhang, Huizhen, Wang, Yongtao, Guan, Lihuan, Chen, Yixin, Chen, Panpan, Sun, Jiahong, Gonzalez, Frank J., Huang, Min, Bi, Huichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264383/
https://www.ncbi.nlm.nih.gov/pubmed/34277122
http://dx.doi.org/10.1016/j.jpha.2020.04.004