Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function

OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation,...

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Detalles Bibliográficos
Autores principales: O’Brien, Aisling, Hanlon, Megan Mary, Marzaioli, Viviana, Wade, Siobhan C., Flynn, Keelin, Fearon, Ursula, Veale, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264423/
https://www.ncbi.nlm.nih.gov/pubmed/34248953
http://dx.doi.org/10.3389/fimmu.2021.672461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264423/
https://www.ncbi.nlm.nih.gov/pubmed/34248953
http://dx.doi.org/10.3389/fimmu.2021.672461

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