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Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function
OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation,...
Autores principales: | O’Brien, Aisling, Hanlon, Megan Mary, Marzaioli, Viviana, Wade, Siobhan C., Flynn, Keelin, Fearon, Ursula, Veale, Douglas J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264423/ https://www.ncbi.nlm.nih.gov/pubmed/34248953 http://dx.doi.org/10.3389/fimmu.2021.672461 |
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