Cargando…

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease

Coronaviruses are responsible for multiple pandemics and millions of deaths globally, including the current pandemic of coronavirus disease 2019 (COVID-19). Development of antivirals against coronaviruses, including the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) responsible for COV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferreira, Juliana C., Fadl, Samar, Villanueva, Adrian J., Rabeh, Wael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264439/ https://www.ncbi.nlm.nih.gov/pubmed/34249864 http://dx.doi.org/10.3389/fchem.2021.692168

Ejemplares similares

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity
por: Al Adem, Kenana, et al.
Publicado: (2022)

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
por: Ferreira, Juliana C., et al.
Publicado: (2022)

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro
por: Ferreira, Juliana C., et al.
Publicado: (2021)

Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2
por: Ferreira, Juliana C., et al.
Publicado: (2020)

Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad
por: Sanchez-Pulido, Luis, et al.
Publicado: (2016)

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors
por: Kovalevsky, Andrey, et al.
Publicado: (2023)

Novel dimer structure of a membrane-bound protease with a catalytic Ser–Lys dyad and its linkage to stomatin
por: Yokoyama, Hideshi, et al.
Publicado: (2008)

Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin
por: Cleary, Jennifer A., et al.
Publicado: (2014)

Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice
por: Mosztbacher, Dóra, et al.
Publicado: (2020)

Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid.
por: Lia, Andrea, et al.
Publicado: (2020)

Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’
por: Horn, Martin, et al.
Publicado: (2014)

Structural comparison strengthens the higher-order classification of proteases related to chymotrypsin
por: Mönttinen, Heli A. M., et al.
Publicado: (2019)

Directed evolution improves the catalytic efficiency of TEV protease
por: Sanchez, Mateo I, et al.
Publicado: (2019)

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL
por: Lysyk, Laine, et al.
Publicado: (2021)

Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis
por: Clark, Elizabeth A., et al.
Publicado: (2011)

The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
por: Kosinski, Richard, et al.
Publicado: (2022)

Investigation on substrate specificity and catalytic activity of serine protease neuropsin
por: Lintuluoto, Masami, et al.
Publicado: (2022)

Enhanced Azidolysis by the Formation of Stable Ser–His Catalytic Dyad in a Glycoside Hydrolase Family 10 Xylanase Mutant
por: Suzuki, Ryuichiro, et al.
Publicado: (2018)

An investigation into the applicability of the semiempirical method PM7 for modeling the catalytic mechanism in the enzyme chymotrypsin
por: Stewart, James J. P.
Publicado: (2017)

Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses
por: Lim, Liangzhong, et al.
Publicado: (2019)

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus
por: Hartini, Yustina, et al.
Publicado: (2021)

Product release is rate-limiting for catalytic processing by the Dengue virus protease
por: Shannon, A. E., et al.
Publicado: (2016)

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics
por: Gupta, Garvita, et al.
Publicado: (2015)

Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma
por: Kylmä, Anna Kaisa, et al.
Publicado: (2018)

Pharmacoinformatic study of inhibitory potentials of selected flavonoids against papain-like protease and 3-chymotrypsin-like protease of SARS-CoV-2
por: Tijjani, Habibu, et al.
Publicado: (2022)

Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase
por: Barman, Arghya, et al.
Publicado: (2014)

Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
por: Zhao, Zhao, et al.
Publicado: (2016)

Consequences of the loss of catalytic triads in chloroplast CLPPR protease core complexes in vivo
por: Liao, Jui‐Yun Rei, et al.
Publicado: (2018)

Enhanced catalytic activity of Bacillus aryabhattai P1 protease by modulation with nanoactivator
por: Pathak, Anupama P., et al.
Publicado: (2020)

Improving the catalytic activity of a detergent‐compatible serine protease by rational design
por: Wang, Xiao, et al.
Publicado: (2023)

Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets
por: Romei, Matthew G., et al.
Publicado: (2023)

Evaluation of Catalytic Effects of Chymotrypsin and Cu(2+) for Development of UV-Spectroscopic Method for Gelatin-Source Differentiation
por: Hamizah, Anis, et al.
Publicado: (2017)

Inhibition of Melanization by a Parasitoid Serine Protease Homolog Venom Protein Requires Both the Clip and the Non-Catalytic Protease-Like Domains
por: Thomas, Pune, et al.
Publicado: (2011)

Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions
por: Huang, Liangqun, et al.
Publicado: (2011)

Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis
por: Zögg, Thomas, et al.
Publicado: (2013)

DWV 3C Protease Uncovers the Diverse Catalytic Triad in Insect RNA Viruses
por: Yuan, Xuye, et al.
Publicado: (2022)

NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases
por: Denesyuk, Alexander I., et al.
Publicado: (2020)

Cloning a Chymotrypsin-Like 1 (CTRL-1) Protease cDNA from the Jellyfish Nemopilema nomurai
por: Heo, Yunwi, et al.
Publicado: (2016)

Multispectroscopic and Computational Analysis Insight into the Interaction of Cationic Diester-Bonded Gemini Surfactants with Serine Protease α-Chymotrypsin
por: Akram, Mohd., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_icsdn9q9d7hibplbk6okp7i8dr