New Approach to Drug Discovery of a Safe Mitochondrial Uncoupler: OPC-163493

[Image: see text] We serendipitously found a mitochondrial uncoupler (mUncoupler), compound 1, in the process of screening for inhibitors of a gene product related to calorie restriction (CR) and longevity. Compound 1 has a unique 4-cyano-1,2,3-triazole structure which is different from any known mU...

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Detalles Bibliográficos
Autores principales: Okamoto, Takashi, Shimada, Takahiro, Matsumura, Chiharu, Minoshima, Hitomi, Ban, Takashi, Itotani, Motohiro, Shinohara, Toshio, Fujita, Shigekazu, Matsuda, Satoshi, Sato, Seiji, Kanemoto, Naohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264940/
https://www.ncbi.nlm.nih.gov/pubmed/34250356
http://dx.doi.org/10.1021/acsomega.1c01993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264940/
https://www.ncbi.nlm.nih.gov/pubmed/34250356
http://dx.doi.org/10.1021/acsomega.1c01993

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