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New Approach to Drug Discovery of a Safe Mitochondrial Uncoupler: OPC-163493
[Image: see text] We serendipitously found a mitochondrial uncoupler (mUncoupler), compound 1, in the process of screening for inhibitors of a gene product related to calorie restriction (CR) and longevity. Compound 1 has a unique 4-cyano-1,2,3-triazole structure which is different from any known mU...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264940/ https://www.ncbi.nlm.nih.gov/pubmed/34250356 http://dx.doi.org/10.1021/acsomega.1c01993 |