Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

BACKGROUND: Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the prevalent mutations in codon 12 and 13 of KRAS have all been linked to different clinical outcomes, but the molecular mechanisms be...

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Detalles Bibliográficos
Autores principales: Kundu, Snehangshu, Ali, Muhammad Akhtar, Handin, Niklas, Conway, Louis P., Rendo, Veronica, Artursson, Per, He, Liqun, Globisch, Daniel, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265010/
https://www.ncbi.nlm.nih.gov/pubmed/34233735
http://dx.doi.org/10.1186/s13046-021-02025-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265010/
https://www.ncbi.nlm.nih.gov/pubmed/34233735
http://dx.doi.org/10.1186/s13046-021-02025-2

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