MTR3D: identifying regions within protein tertiary structures under purifying selection

The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome sequences to over 81,000 experimental structures and homology models of the human proteome, we have calculated both regional intolerance to missense variation (Missense To...

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Detalles Bibliográficos
Autores principales: Silk, Michael, Pires, Douglas E V, Rodrigues, Carlos H M, D’Souza, Elston N, Olshansky, Moshe, Thorne, Natalie, Ascher, David B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Web Server Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265191/
https://www.ncbi.nlm.nih.gov/pubmed/34050760
http://dx.doi.org/10.1093/nar/gkab428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265191/
https://www.ncbi.nlm.nih.gov/pubmed/34050760
http://dx.doi.org/10.1093/nar/gkab428

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