MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart

Radiotherapy remains a mainstay of treatment for a majority of cancer patients. We have previously shown that the membrane bound matrix metalloproteinase MT1-MMP confers radio- and chemotherapy resistance to breast cancer via processing of the ECM and activation of integrinβ1/FAK signaling. Here, we...

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Detalles Bibliográficos
Autores principales: Thakur, Varsha, Tiburcio de Freitas, Juliano, Li, Yuan, Zhang, Keman, Savadelis, Alyssa, Bedogni, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266045/
https://www.ncbi.nlm.nih.gov/pubmed/34237080
http://dx.doi.org/10.1371/journal.pone.0253062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266045/
https://www.ncbi.nlm.nih.gov/pubmed/34237080
http://dx.doi.org/10.1371/journal.pone.0253062

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