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Gemcitabine-induced Gli-dependent activation of hedgehog pathway resists to the treatment of urothelial carcinoma cells
Patients with urothelial carcinoma (UC) experience gemcitabine resistance is a critical issue. The role of hedgehog pathway in the problem was explored. The expressions of phospho-AKT(ser473), phospho-GSK3β(ser9) and Gli2 were up-regulated in gemcitabine-resistant NTUB1 (NGR) cells. Without hedgehog...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266077/ https://www.ncbi.nlm.nih.gov/pubmed/34237099 http://dx.doi.org/10.1371/journal.pone.0254011 |