Cargando…

NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells

Microglia are the resident immune cell of the brain involved in the development and progression of Alzheimer’s disease (AD). Modulation of microglia activity represents a potential mechanism for treating AD. Herein, the compound NNC 26–9100 (NNC) was evaluated in toxicity, nitric oxide release, Aβ(1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schober, Joseph, Polina, Jahnavi, Walters, Field, Scott, Nathan, Lodholz, Eric, Crider, Albert, Sandoval, Karin, Witt, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266108/ https://www.ncbi.nlm.nih.gov/pubmed/34237100 http://dx.doi.org/10.1371/journal.pone.0254242

Ejemplares similares

Complete genome sequence of Streptosporangium roseum type strain (NI 9100(T))
por: Nolan, Matt, et al.
Publicado: (2010)

Effects of Immunomodulatory Substances on Phagocytosis of Aβ (1–42) by Human Microglia
por: Hjorth, Erik, et al.
Publicado: (2010)

Effects of α-Lipoic Acid on Phagocytosis of Oligomeric Beta-Amyloid(1–42) in BV-2 Mouse Microglial Cells
por: Ko, Chih-Yuan, et al.
Publicado: (2022)

Platinum(IV) Complexes with Tridentate, NNC-Coordinating Ligands: Synthesis, Structures, and Luminescence
por: Dikova, Yana M., et al.
Publicado: (2023)

Morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of Trypanosoma brucei
por: Figarella, Katherine, et al.
Publicado: (2018)

The effects of insulin on the inflammatory activity of BV2 microglia
por: Brabazon, Fiona, et al.
Publicado: (2018)

Neuroprotection by Skimmianine in Lipopolysaccharide-Activated BV-2 Microglia
por: Ogunrinade, Folashade A., et al.
Publicado: (2023)

An Oligomannuronic Acid-Sialic Acid Conjugate Capable of Inhibiting Aβ42 Aggregation and Alleviating the Inflammatory Response of BV-2 Microglia
por: Wu, Jianrong, et al.
Publicado: (2021)

Aging and sex: Impact on microglia phagocytosis
por: Yanguas‐Casás, Natalia, et al.
Publicado: (2020)

Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
por: Park, Sung Hee, et al.
Publicado: (2021)

The CD33 short isoform is a gain-of-function variant that enhances Aβ(1–42) phagocytosis in microglia
por: Bhattacherjee, Abhishek, et al.
Publicado: (2021)

A Mutagenesis Assay for Reporter Gene Screening Using Partially Degenerate Oligonucleotides of the Tandems NNT and NNC
por: Xu, Huifen, et al.
Publicado: (2015)

Four-Coordinate Fe N(2) and Imido Complexes Supported by a Hemilabile NNC Heteroscorpionate Ligand
por: McSkimming, Alex, et al.
Publicado: (2022)

Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells
por: Kučić, Natalia, et al.
Publicado: (2021)

α-Tocopherol Protects Lipopolysaccharide-Activated BV2 Microglia
por: La Torre, Maria Ester, et al.
Publicado: (2023)

Phagocytosis of Microglia in the Central Nervous System Diseases
por: Fu, Ruying, et al.
Publicado: (2014)

Comparative Review of Microglia and Monocytes in CNS Phagocytosis
por: Andoh, Megumi, et al.
Publicado: (2021)

Regulation of microglia phagocytosis and potential involvement of exercise
por: Li, Congqin, et al.
Publicado: (2022)

The miR172c-NNC1 module modulates root plastic development in response to salt in soybean
por: Sahito, Zulfiqar Ali, et al.
Publicado: (2017)

Flavonoids isolated from Lespedeza cuneata G. Don and their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglia cells
por: Yoo, Guijae, et al.
Publicado: (2015)

Cdc42 interacts with the exocyst complex to promote phagocytosis
por: Mohammadi, Sina, et al.
Publicado: (2013)

Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia
por: Lei, Beilei, et al.
Publicado: (2014)

Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells
por: Bozic, Iva, et al.
Publicado: (2015)

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia
por: Bozic, Iva, et al.
Publicado: (2015)

Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia
por: Zhou, Dingzhou, et al.
Publicado: (2019)

Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia
por: Hu, Yawen, et al.
Publicado: (2022)

A simplified procedure for isolation of primary murine microglia
por: Scott, Nathan, et al.
Publicado: (2022)

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
por: Cockram, Tom O. J., et al.
Publicado: (2019)

The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia
por: Fleiss, Bobbi, et al.
Publicado: (2015)

Antineuroinflammatory and Neuroprotective Effects of Gyejibokryeong-Hwan in Lipopolysaccharide-Stimulated BV2 Microglia
por: Park, Bo-Kyung, et al.
Publicado: (2019)

Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
por: Li, Cheng, et al.
Publicado: (2023)

Nimbolide Targets Multiple Signalling Pathways to Reduce Neuroinflammation in BV-2 Microglia
por: Katola, Folashade O., et al.
Publicado: (2023)

Spherical Ni/NiO nanoparticles decorated on nanoporous carbon (NNC) as an active electrode material for urea and water oxidation reactions
por: Chavan, Parag P., et al.
Publicado: (2023)

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia
por: Yuan, Yun, et al.
Publicado: (2014)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
por: Neher, Jonas J., et al.
Publicado: (2012)

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
por: Sierra, Amanda, et al.
Publicado: (2013)

Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine
por: Fan, Yang, et al.
Publicado: (2018)

Transcriptional signature in microglia associated with Aβ plaque phagocytosis
por: Grubman, Alexandra, et al.
Publicado: (2021)

Protocol for assessing phagocytosis activity in cultured primary murine microglia
por: Layman, Elsie, et al.
Publicado: (2022)

AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia
por: Velagapudi, Ravikanth, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gdbq1pn6gaqp0l78rr9p36agl7