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Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice
Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline DENV immunity may influence subsequent ZIKV infection and the protective efficacy of ZIKV vaccines. In this study, we investigated the impact o...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266125/ https://www.ncbi.nlm.nih.gov/pubmed/34170962 http://dx.doi.org/10.1371/journal.ppat.1009673 |
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author | Larocca, Rafael A. Abbink, Peter Ventura, John D. Chandrashekar, Abishek Mercado, Noe Li, Zhenfeng Borducchi, Erica De La Barrera, Rafael A. Eckels, Kenneth H. Modjarrad, Kayvon Busch, Michael P. Michael, Nelson L. Barouch, Dan H. |
author_facet | Larocca, Rafael A. Abbink, Peter Ventura, John D. Chandrashekar, Abishek Mercado, Noe Li, Zhenfeng Borducchi, Erica De La Barrera, Rafael A. Eckels, Kenneth H. Modjarrad, Kayvon Busch, Michael P. Michael, Nelson L. Barouch, Dan H. |
author_sort | Larocca, Rafael A. |
collection | PubMed |
description | Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline DENV immunity may influence subsequent ZIKV infection and the protective efficacy of ZIKV vaccines. In this study, we investigated the impact of pre-existing DENV immunity induced by vaccination on ZIKV infection and the protective efficacy of an inactivated ZIKV vaccine. Rhesus macaques and mice inoculated with a live attenuated DENV vaccine developed neutralizing antibodies (NAbs) to multiple DENV serotypes but no cross-reactive NAbs responses to ZIKV. Animals with baseline DENV NAbs did not exhibit enhanced ZIKV infection and showed no overall reduction in ZIKV vaccine protection. Moreover, passive transfer of purified DENV-specific IgG from convalescent human donors did not augment ZIKV infection in STAT2 (-/-) and BALB/c mice. In summary, these results suggest that baseline DENV immunity induced by vaccination does not significantly enhance ZIKV infection or impair the protective efficacy of candidate ZIKV vaccines in these models. These data can help inform immunization strategies in regions of the world with multiple circulating pathogenic flaviviruses. |
format | Online Article Text |
id | pubmed-8266125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82661252021-07-19 Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice Larocca, Rafael A. Abbink, Peter Ventura, John D. Chandrashekar, Abishek Mercado, Noe Li, Zhenfeng Borducchi, Erica De La Barrera, Rafael A. Eckels, Kenneth H. Modjarrad, Kayvon Busch, Michael P. Michael, Nelson L. Barouch, Dan H. PLoS Pathog Research Article Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline DENV immunity may influence subsequent ZIKV infection and the protective efficacy of ZIKV vaccines. In this study, we investigated the impact of pre-existing DENV immunity induced by vaccination on ZIKV infection and the protective efficacy of an inactivated ZIKV vaccine. Rhesus macaques and mice inoculated with a live attenuated DENV vaccine developed neutralizing antibodies (NAbs) to multiple DENV serotypes but no cross-reactive NAbs responses to ZIKV. Animals with baseline DENV NAbs did not exhibit enhanced ZIKV infection and showed no overall reduction in ZIKV vaccine protection. Moreover, passive transfer of purified DENV-specific IgG from convalescent human donors did not augment ZIKV infection in STAT2 (-/-) and BALB/c mice. In summary, these results suggest that baseline DENV immunity induced by vaccination does not significantly enhance ZIKV infection or impair the protective efficacy of candidate ZIKV vaccines in these models. These data can help inform immunization strategies in regions of the world with multiple circulating pathogenic flaviviruses. Public Library of Science 2021-06-25 /pmc/articles/PMC8266125/ /pubmed/34170962 http://dx.doi.org/10.1371/journal.ppat.1009673 Text en © 2021 Larocca et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Larocca, Rafael A. Abbink, Peter Ventura, John D. Chandrashekar, Abishek Mercado, Noe Li, Zhenfeng Borducchi, Erica De La Barrera, Rafael A. Eckels, Kenneth H. Modjarrad, Kayvon Busch, Michael P. Michael, Nelson L. Barouch, Dan H. Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title | Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title_full | Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title_fullStr | Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title_full_unstemmed | Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title_short | Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice |
title_sort | impact of prior dengue immunity on zika vaccine protection in rhesus macaques and mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266125/ https://www.ncbi.nlm.nih.gov/pubmed/34170962 http://dx.doi.org/10.1371/journal.ppat.1009673 |
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