Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study

New cyanobenzofurans derivatives 2–12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC(50) = 4.17–8.87 and 5.5–11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activity against HePG2 (IC(50) = 16.08–23.67 µM), HCT-116 (IC(...

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Detalles Bibliográficos
Autores principales: Fares, Salma, Selim, Khalid B., Goda, Fatma E., El-Sayed, Magda A. A., AlSaif, Nawaf A., Hefnawy, Mohamed M., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266232/
https://www.ncbi.nlm.nih.gov/pubmed/34227457
http://dx.doi.org/10.1080/14756366.2021.1946044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266232/
https://www.ncbi.nlm.nih.gov/pubmed/34227457
http://dx.doi.org/10.1080/14756366.2021.1946044

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