Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

This study describes the synthesis and vacuole-inducing activity of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carbohydrazide derivatives, including five potent derivatives 12c, 12 g, 12i, 12n, and 12A that exhibit excellent vacuole-inducing activity. Remarkably, 12A effectively induces m...

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Detalles Bibliográficos
Autores principales: Wu, Jun, Hu, Hongyu, Ao, Mingtao, Cui, Zhenzhen, Zhou, Xiaoping, Qin, Jingbo, Guo, Yafei, Chen, Jingwei, Xue, Yuhua, Fang, Meijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266240/
https://www.ncbi.nlm.nih.gov/pubmed/34229558
http://dx.doi.org/10.1080/14756366.2021.1940992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266240/
https://www.ncbi.nlm.nih.gov/pubmed/34229558
http://dx.doi.org/10.1080/14756366.2021.1940992

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