Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 p...

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Detalles Bibliográficos
Autores principales: Sinreih, Maša, Jójárt, Rebeka, Kele, Zoltán, Büdefeld, Tomaž, Paragi, Gábor, Mernyák, Erzsébet, Rižner, Tea Lanišnik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266253/
https://www.ncbi.nlm.nih.gov/pubmed/34227437
http://dx.doi.org/10.1080/14756366.2021.1937142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266253/
https://www.ncbi.nlm.nih.gov/pubmed/34227437
http://dx.doi.org/10.1080/14756366.2021.1937142

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