Cargando…

Chemical and photochemical error rates in light-directed synthesis of complex DNA libraries

Nucleic acid microarrays are the only tools that can supply very large oligonucleotide libraries, cornerstones of the nascent fields of de novo gene assembly and DNA data storage. Although the chemical synthesis of oligonucleotides is highly developed and robust, it is not error free, requiring the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lietard, Jory, Leger, Adrien, Erlich, Yaniv, Sadowski, Norah, Timp, Winston, Somoza, Mark M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266620/ https://www.ncbi.nlm.nih.gov/pubmed/34157124 http://dx.doi.org/10.1093/nar/gkab505

Ejemplares similares

Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays
por: Lietard, Jory, et al.
Publicado: (2017)

A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine
por: Zhou, Fang, et al.
Publicado: (2022)

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA
por: Cadoni, Enrico, et al.
Publicado: (2023)

Directly lighting up RNA G-quadruplexes from test tubes to living human cells
por: Xu, Shujuan, et al.
Publicado: (2015)

Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension
por: Duzdevich, Daniel, et al.
Publicado: (2021)

Chemical ligation of oligonucleotides using an electrophilic phosphorothioester
por: Maruyama, Hideto, et al.
Publicado: (2017)

A randomized library approach to identifying functional lox site domains for the Cre recombinase
por: Sheren, Jamie, et al.
Publicado: (2007)

The high fidelity and unique error signature of human DNA polymerase ε
por: Korona, Dagmara A., et al.
Publicado: (2011)

Landscape of the complete RNA chemical modifications in the human 80S ribosome
por: Taoka, Masato, et al.
Publicado: (2018)

Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides
por: Onizuka, Kazumitsu, et al.
Publicado: (2017)

Chemical genetic inhibition of DEAD-box proteins using covalent complementarity
por: Barkovich, Krister J, et al.
Publicado: (2018)

Principles of chemical geometry underlying chiral selectivity in RNA minihelix aminoacylation
por: Ando, Tadashi, et al.
Publicado: (2018)

Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification
por: Baker, Ysobel R, et al.
Publicado: (2021)

Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides
por: Yoshida, Tokuyuki, et al.
Publicado: (2022)

Constraints on error rate revealed by computational study of G•U tautomerization in translation
por: Kazantsev, Andriy, et al.
Publicado: (2021)

Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library
por: Li, Jiuxing, et al.
Publicado: (2021)

Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases
por: Raindlová, Veronika, et al.
Publicado: (2016)

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
por: McGorman, Bríonna, et al.
Publicado: (2022)

Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries
por: Randrianjatovo-Gbalou, Irina, et al.
Publicado: (2018)

New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem
por: Zhang, Canyu, et al.
Publicado: (2021)

RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase δ
por: Fortune, John M., et al.
Publicado: (2006)

Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore
por: Terai, Yuma, et al.
Publicado: (2020)

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
por: Hassler, Matthew R, et al.
Publicado: (2018)

Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation
por: Habibian, Maryam, et al.
Publicado: (2018)

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy
por: Biscans, Annabelle, et al.
Publicado: (2020)

Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA
por: Uehara, Keiji, et al.
Publicado: (2022)

Conjugation of chemical handles and functional moieties to DNA during solid phase synthesis with sulfonyl azides
por: Santorelli, Angel, et al.
Publicado: (2022)

Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin
por: Beniaminov, Artemy D., et al.
Publicado: (2016)

Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes
por: Kumar, Rajendra, et al.
Publicado: (2020)

Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA
por: Price, Nathan E., et al.
Publicado: (2015)

Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity
por: O’Reilly, Daniel, et al.
Publicado: (2019)

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
por: Gaus, Hans J, et al.
Publicado: (2019)

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins
por: Guilliam, Thomas A., et al.
Publicado: (2015)

Cavity hairpin ThT-light nucleic acid switches: the construction of label- and enzyme-free sensing and imaging platforms
por: Lan, Xinyue, et al.
Publicado: (2023)

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
por: Shan, Chan, et al.
Publicado: (2015)

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis
por: Álvarez, Mar, et al.
Publicado: (2013)

Time-lapse imaging of molecular evolution by high-throughput sequencing
por: Nguyen Quang, Nam, et al.
Publicado: (2018)

HU binds and folds single-stranded DNA
por: Kamashev, Dmitri, et al.
Publicado: (2008)

Red light-emitting short Mango-based system enables tracking a mycobacterial small noncoding RNA in infected macrophages
por: Bychenko, Oksana S, et al.
Publicado: (2023)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7sr3bahlu5eomf0qk7e30o919p