A new assay capturing chromosome fusions shows a protection trade-off at telomeres and NHEJ vulnerability to low-density ionizing radiation

Chromosome fusions threaten genome integrity and promote cancer by engaging catastrophic mutational processes, namely chromosome breakage–fusion–bridge cycles and chromothripsis. Chromosome fusions are frequent in cells incurring telomere dysfunctions or those exposed to DNA breakage. Their occurren...

Descripción completa

Detalles Bibliográficos
Autores principales: Pobiega, Sabrina, Alibert, Olivier, Marcand, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266670/
https://www.ncbi.nlm.nih.gov/pubmed/34125900
http://dx.doi.org/10.1093/nar/gkab502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266670/
https://www.ncbi.nlm.nih.gov/pubmed/34125900
http://dx.doi.org/10.1093/nar/gkab502

Ejemplares similares