Identification of V6.51L as a selectivity hotspot in stereoselective A(2B) adenosine receptor antagonist recognition

The four adenosine receptors (ARs) A(1)AR, A(2A)AR, A(2B)AR(,) and A(3)AR are G protein-coupled receptors (GPCRs) for which an exceptional amount of experimental and structural data is available. Still, limited success has been achieved in getting new chemical modulators on the market. As such, ther...

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Detalles Bibliográficos
Autores principales: Wang, Xuesong, Jespers, Willem, Prieto-Díaz, Rubén, Majellaro, Maria, IJzerman, Adriaan P., van Westen, Gerard J. P., Sotelo, Eddy, Heitman, Laura H., Gutiérrez-de-Terán, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266863/
https://www.ncbi.nlm.nih.gov/pubmed/34238993
http://dx.doi.org/10.1038/s41598-021-93419-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266863/
https://www.ncbi.nlm.nih.gov/pubmed/34238993
http://dx.doi.org/10.1038/s41598-021-93419-x

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