Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain (hallmarks of HD implicated in neurotoxicity) remain elusive...

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Detalles Bibliográficos
Autores principales: Galaz-Montoya, Jesús G., Shahmoradian, Sarah H., Shen, Koning, Frydman, Judith, Chiu, Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266869/
https://www.ncbi.nlm.nih.gov/pubmed/34239038
http://dx.doi.org/10.1038/s42003-021-02360-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266869/
https://www.ncbi.nlm.nih.gov/pubmed/34239038
http://dx.doi.org/10.1038/s42003-021-02360-2

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