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Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway

PURPOSE: Is it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments by inhibition of Aurora B/C kinases (AURKB/C) without compromising ovarian tissue or follicles? METHODS: Human ovarian cortex tissue with experiment...

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Detalles Bibliográficos
Autores principales:	Eijkenboom, Lotte, Mulder, Callista, van der Reijden, Bert, van Mello, Norah, van Leersum, Julia, Koorenhof-Scheele, Thessa, Braat, Didi, Beerendonk, Catharina, Peek, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Fertility Preservation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266964/ https://www.ncbi.nlm.nih.gov/pubmed/33725274 http://dx.doi.org/10.1007/s10815-021-02081-9

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