Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway

PURPOSE: Is it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments by inhibition of Aurora B/C kinases (AURKB/C) without compromising ovarian tissue or follicles? METHODS: Human ovarian cortex tissue with experiment...

Descripción completa

Detalles Bibliográficos
Autores principales: Eijkenboom, Lotte, Mulder, Callista, van der Reijden, Bert, van Mello, Norah, van Leersum, Julia, Koorenhof-Scheele, Thessa, Braat, Didi, Beerendonk, Catharina, Peek, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Fertility Preservation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266964/
https://www.ncbi.nlm.nih.gov/pubmed/33725274
http://dx.doi.org/10.1007/s10815-021-02081-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266964/
https://www.ncbi.nlm.nih.gov/pubmed/33725274
http://dx.doi.org/10.1007/s10815-021-02081-9

Ejemplares similares