In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K

Benzimidazole-2-carbamate (BZ) compounds, including Albendazole (Alb), are one of just two drug classes approved to treat the gastrointestinal protist Giardia duodenalis. Benzimidazoles bind to the tubulin dimer interface overlapping the colchicine binding site (CBS) of β-tubulin, thereby inhibiting...

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Detalles Bibliográficos
Autores principales: Emery-Corbin, Samantha J., Su, Qiao, Tichkule, Swapnil, Baker, Louise, Lacey, Ernest, Jex, Aaron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267433/
https://www.ncbi.nlm.nih.gov/pubmed/34237690
http://dx.doi.org/10.1016/j.ijpddr.2021.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267433/
https://www.ncbi.nlm.nih.gov/pubmed/34237690
http://dx.doi.org/10.1016/j.ijpddr.2021.05.003

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