Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s Esophagus

BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) develops from its precursor Barrett’s esophagus through intermediate stages of low- and high-grade dysplasia. However, knowledge of genetic drivers and molecular mechanisms implicated in disease progression is limited. Herein, we investigated th...

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Detalles Bibliográficos
Autores principales: Gotovac, Jovana R., Kader, Tanjina, Milne, Julia V., Fujihara, Kenji M., Lara-Gonzalez, Luis E., Gorringe, Kylie L., Kalimuthu, Sangeetha N., Jayawardana, Madawa W., Duong, Cuong P., Phillips, Wayne A., Clemons, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267443/
https://www.ncbi.nlm.nih.gov/pubmed/33774196
http://dx.doi.org/10.1016/j.jcmgh.2021.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267443/
https://www.ncbi.nlm.nih.gov/pubmed/33774196
http://dx.doi.org/10.1016/j.jcmgh.2021.03.008

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