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Contiguous erosion of the inactive X in human pluripotency concludes with global DNA hypomethylation
Female human pluripotent stem cells (hPSCs) routinely undergo inactive X (Xi) erosion. This progressive loss of key repressive features follows the loss of XIST expression, the long non-coding RNA driving X inactivation, and causes reactivation of silenced genes across the eroding X (Xe). To date, t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267460/ https://www.ncbi.nlm.nih.gov/pubmed/34107261 http://dx.doi.org/10.1016/j.celrep.2021.109215 |