De novo ssRNA Aptamers against the SARS-CoV-2 Main Protease: In Silico Design and Molecular Dynamics Simulation

Herein, we have generated ssRNA aptamers to inhibit SARS-CoV-2 M(pro), a protease necessary for the SARS-CoV-2 coronavirus replication. Because there is no aptamer 3D structure currently available in the databanks for this protein, first, we modeled an ssRNA aptamer using an entropic fragment-based...

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Detalles Bibliográficos
Autores principales: Morena, Francesco, Argentati, Chiara, Tortorella, Ilaria, Emiliani, Carla, Martino, Sabata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267631/
https://www.ncbi.nlm.nih.gov/pubmed/34206794
http://dx.doi.org/10.3390/ijms22136874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267631/
https://www.ncbi.nlm.nih.gov/pubmed/34206794
http://dx.doi.org/10.3390/ijms22136874

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