Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model

Inactivating mutations in ABCC6 underlie the rare hereditary mineralization disorder pseudoxanthoma elasticum. ABCC6 is an ATP-binding cassette (ABC) integral membrane protein that mediates the release of ATP from hepatocytes into the bloodstream. The released ATP is extracellularly converted into p...

Descripción completa

Detalles Bibliográficos
Autores principales: Szeri, Flora, Corradi, Valentina, Niaziorimi, Fatemeh, Donnelly, Sylvia, Conseil, Gwenaëlle, Cole, Susan P. C., Tieleman, D. Peter, van de Wetering, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267652/
https://www.ncbi.nlm.nih.gov/pubmed/34199119
http://dx.doi.org/10.3390/ijms22136910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267652/
https://www.ncbi.nlm.nih.gov/pubmed/34199119
http://dx.doi.org/10.3390/ijms22136910

Ejemplares similares