Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model

Inactivating mutations in ABCC6 underlie the rare hereditary mineralization disorder pseudoxanthoma elasticum. ABCC6 is an ATP-binding cassette (ABC) integral membrane protein that mediates the release of ATP from hepatocytes into the bloodstream. The released ATP is extracellularly converted into p...

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Detalles Bibliográficos
Autores principales: Szeri, Flora, Corradi, Valentina, Niaziorimi, Fatemeh, Donnelly, Sylvia, Conseil, Gwenaëlle, Cole, Susan P. C., Tieleman, D. Peter, van de Wetering, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267652/
https://www.ncbi.nlm.nih.gov/pubmed/34199119
http://dx.doi.org/10.3390/ijms22136910

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