Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency

The ‘shock-and-kill’ strategy to purge the latent HIV reservoir relies on latency-reversing agents (LRAs) to reactivate the provirus and subsequent immune-mediated killing of HIV-expressing cells. Yet, clinical trials employing histone deacetylase inhibitors (HDACis; Vorinostat, Romidepsin, Panobino...

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Detalles Bibliográficos
Autores principales: Covino, Daniela A., Desimio, Maria G., Doria, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267728/
https://www.ncbi.nlm.nih.gov/pubmed/34206330
http://dx.doi.org/10.3390/ijms22136654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267728/
https://www.ncbi.nlm.nih.gov/pubmed/34206330
http://dx.doi.org/10.3390/ijms22136654

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