Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma

SIMPLE SUMMARY: Darifenacin is a selective muscarinic acetylcholine receptor 3 (M3R) antagonist in clinical use for benign bladder disorders. Here, the effects of M3R blockage by darifenacin on human colon adenocarcinoma cells are analyzed in vitro and in vivo. M3R expression was found in the majori...

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Detalles Bibliográficos
Autores principales: Hering, Nina A., Liu, Verena, Kim, Rayoung, Weixler, Benjamin, Droeser, Raoul A., Arndt, Marco, Pozios, Ioannis, Beyer, Katharina, Kreis, Martin E., Seeliger, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267754/
https://www.ncbi.nlm.nih.gov/pubmed/34203220
http://dx.doi.org/10.3390/cancers13133220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267754/
https://www.ncbi.nlm.nih.gov/pubmed/34203220
http://dx.doi.org/10.3390/cancers13133220

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