Cargando…

Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold

Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a–p) have been developed as a safer and more efficient multitarget therapeutic strate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sava, Alexandru, Buron, Frederic, Routier, Sylvain, Panainte, Alina, Bibire, Nela, Constantin, Sandra Mădălina, Lupașcu, Florentina Geanina, Focșa, Alin Viorel, Profire, Lenuţa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267937/ https://www.ncbi.nlm.nih.gov/pubmed/34209248 http://dx.doi.org/10.3390/ijms22137079

Ejemplares similares

Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold
por: Constantin, Sandra, et al.
Publicado: (2017)

Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold
por: Constantin, Sandra Madalina, et al.
Publicado: (2019)

The Synthesis and the Biological Evaluation of New Thiazolidin-4-one Derivatives Containing a Xanthine Moiety
por: Lupascu, Florentina Geanina, et al.
Publicado: (2013)

Synthesis of novel series of 3,5-disubstituted imidazo[1,2-d] [1,2,4]thiadiazoles involving S(N)Ar and Suzuki–Miyaura cross-coupling reactions
por: Pescheteau, Clémentine, et al.
Publicado: (2022)

Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation
por: Vasincu, Ioana Mirela, et al.
Publicado: (2023)

New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
por: Vasincu, Ioana-Mirela, et al.
Publicado: (2021)

Design, Synthesis and the Biological Evaluation of New 1,3-Thiazolidine-4-ones Based on the 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one Scaffold
por: Apotrosoaei, Maria, et al.
Publicado: (2014)

Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid
por: Vasincu, Ioana Mirela, et al.
Publicado: (2014)

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
por: Iacob, Andreea Teodora, et al.
Publicado: (2021)

New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management
por: Tatarusanu, Simona-Maria, et al.
Publicado: (2023)

Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester
por: Pânzariu, Andreea-Teodora, et al.
Publicado: (2016)

Modern Approaches in Wounds Management
por: Tatarusanu, Simona-Maria, et al.
Publicado: (2023)

Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
por: Dragostin, Oana Maria, et al.
Publicado: (2015)

A Sustainable Approach to a Cleaner Production of Antimicrobial and Biocompatible Protein Fibers
por: Danila, Angela, et al.
Publicado: (2022)

Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety
por: Mohana, Kikkeri N., et al.
Publicado: (2013)

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives
por: Stecoza, Camelia Elena, et al.
Publicado: (2021)

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism
por: Koparır, M., et al.
Publicado: (2005)

Synthesis and Biological Evaluation of New 2-Azetidinones with Sulfonamide Structures
por: Dragostin, Oana Maria, et al.
Publicado: (2013)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives
por: Iacob, Andreea-Teodora, et al.
Publicado: (2018)

Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
por: Moise, Mihaela, et al.
Publicado: (2009)

5-Phenyl-1,3,4-oxadiazol-2-amine
por: Song, Man-Man, et al.
Publicado: (2012)

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
por: Glomb, Teresa, et al.
Publicado: (2018)

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
por: Wang, Qian, et al.
Publicado: (2019)

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
por: Aksenov, Alexander V., et al.
Publicado: (2019)

Collagen-Polyvinyl Alcohol-Indomethacin Biohybrid Matrices as Wound Dressings
por: Marin, Ștefania, et al.
Publicado: (2018)

2-[3,4-Dibutoxy-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-2-thienyl]-5-phenyl-1,3,4-oxadiazole
por: Li, Hai-lin, et al.
Publicado: (2008)

Synthesis, crystal structure and Hirshfeld surface analysis of a zinc(II) coordination polymer of 5-phenyl-1,3,4-oxadiazole-2-thiolate
por: Pirimova, Mehribon, et al.
Publicado: (2022)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
por: Wang, Jing-Jing, et al.
Publicado: (2022)

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole
por: Cordes, David B., et al.
Publicado: (2011)

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
por: Bhat, KI, et al.
Publicado: (2011)

Trifluoromethylpyridine 1,3,4-Oxadiazole Derivatives: Emerging Scaffolds as Bacterial Agents
por: Yu, Gang, et al.
Publicado: (2021)

Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department
por: Caba, Ioana-Cezara, et al.
Publicado: (2022)

Combined Electrochemical, Raman Analysis and Machine Learning Assessments of the Inhibitive Properties of an 1,3,4-Oxadiazole-2-Thiol Derivative against Carbon Steel Corrosion in HCl Solution
por: Varvara, Simona, et al.
Publicado: (2022)

Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles
por: Nagalakshmi, G.
Publicado: (2008)

5-(4-Methylphenyl)-1,3,4-oxadiazol-2-amine
por: Zheng, Juan, et al.
Publicado: (2012)

2,6-Dimethyl-4-(1,3,4-oxadiazol-2-yl)quinoline
por: Kashaev, Artyom G., et al.
Publicado: (2010)

Synthesis and Biological Evaluation of β-Aroylpropionic acid based 1,3,4-Oxadiazoles
por: Husain, A., et al.
Publicado: (2009)

Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
por: Wu, Jian, et al.
Publicado: (2013)

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
por: Bala, Suman, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5n4vtk3ne9jp3jmgclv3pjh9r8