Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis

Dihydroorotase (DHOase) is the third enzyme in the de novo biosynthesis pathway for pyrimidine nucleotides, and an attractive target for potential anticancer chemotherapy. By screening plant extracts and performing GC–MS analysis, we identified and characterized that the potent anticancer drug plumb...

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Detalles Bibliográficos
Autores principales: Guan, Hong-Hsiang, Huang, Yen-Hua, Lin, En-Shyh, Chen, Chun-Jung, Huang, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267945/
https://www.ncbi.nlm.nih.gov/pubmed/34202294
http://dx.doi.org/10.3390/ijms22136861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267945/
https://www.ncbi.nlm.nih.gov/pubmed/34202294
http://dx.doi.org/10.3390/ijms22136861

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